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KMID : 0385019960120010097
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Korean Journal of Laboratory Animal Science
1996 Volume.12 No. 1 p.97 ~ p.102
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Forced Swimming Stress on Physiological Aspects of Spontaneously Hypertensive Rat
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조정식/Cho, Jung Sik
채갑용/장인석/김철규/임철주/황진희/강태석/Chae, Kab Ryong/Jang, In Surk/Kim, Chuel Kyu/Lim, Chuel Joo/Hwang, Jin Hee/Kang, Tae Surk
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Abstract
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Fifty four spontaneously hypertensive rats (SHR) and wistar rats with 10-week old were used in evaluate the efficacy and physiological characteristics animal model for stress. The forced swimming (5 min) was given to animals as a stressor factor arid the durations of forced swimming stressor were 0 day, 3 days and 14 days. In SHR, BUN was tended to be increased, but total amounts of leucocyte and lymphocytes were remarkedly decreased in response to forced swimming stress. In wistar, there were physiologically no significant changes in blood chemical profiles and immunosystems but adrenal weight was increased. The forced swimming stress gave rise to increase in the values of BUN, blood glucose, RBC, and Hgb arid decrease in lymphoid organ weight in STIR compared to those of wistar. These results suggested that SHR responded with declined immunosystem to forced swimming stress compared to those of wistar. In conclusion, SHR might be more sensitive animal model for stress than wistar rats.
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KEYWORD
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